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The Verdict: A novel ingredient with intriguing mechanisms, but human clinical data is needed to confirm safety and effectiveness

Some users might experience mild digestive discomfort

1 A review article of multiple randomized controlled trials reports an average weight loss of around 16% among users, with some losing as much as 17.4%

Semaglutide for diabetes (Ozempic) may be covered while semaglutide for weight loss (Wegovy) is excluded, even though both contain identical active ingredients at similar doses

The site, which provides a robust but not-exhaustive snapshot of clinical trial activity, cites more than 290 unique studies involving the class, while roughly 150 total studies focus on the traditional mainstay, metformin, with roughly 25 studies of those investigating the combined use of GLP-1 receptor agonists with the drug