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GLP-1 Receptor : Like semaglutide, retatrutide activates the GLP-1 receptor, leading to increased insulin production, decreased appetite, and slower stomach emptying

Higher doses of certain GLP-1 medications have subsequently received FDA approval specifically for chronic weight management in adults with a BMI 30 kg/m or 27 kg/m with at least one weight-related comorbidity

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It presents these as the main levers available to cash-paying patients alongside health savings account eligibility