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While regulation of iron metabolism-related proteins or the use of iron chelators can reduce intracellular labile Fe 2+ levels and inhibit ferroptosis, current chelators lack tissue and cellular specificity and may interfere with neurophysiological functions, thereby limiting their clinical applicability
Bioequivalence Analysis For EMA bioequivalence analysis, co-primary endpoints were log-transformed and analysed separately using an analysis of variance (ANOVA) model with treatment (2G oral semaglutide or 1G oral semaglutide), period (PK-sampling visits), sequence (starting with 2G oral semaglutide or 1G oral semaglutide) and participant nested within sequence as fixed effects
Inclusion & Exclusion Criteria
Jaundice (yellowing of the skin or eyes)
6d, g and Supplementary Fig
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