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It increases the release of norepinephrine and decreases its uptake in hypothalamic nuclei, thus resulting in decreased food intake

The receptor is a glycoprotein that, like all G protein-coupled receptors, has a seven-transmembrane helix domain and an N-terminal extracellular signal peptide [7]

doi: 10.3389/fphar.2025.1640365 Received 03 June 2025 Accepted 22 August 2025 Published 01 September 2025 Volume 16 - 2025 Edited by Jinbong Park, Kyung Hee University, Republic of Korea Reviewed by Wangbin Wu, University of Cincinnati, United States Nilkamal Mahanta, Indian Institute of Technology Dharwad, India Fahad Khan, Saveetha Medical College & Hospital, India Updates Copyright 2025 Shi, Ni, Kong, Ren, Shi, Xu, Qu, Zhou and Zhang

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