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MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism
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Composition 5-amino-1MQ: 50 mg Appearance: lyophilized powder in a sealed research vial Research Focus (non-clinical) Investigation of NNMT inhibition and its downstream metabolic effects Studies on NAD+ metabolism and energy homeostasis in preclinical models Development of analytical methods (HPLC/LC-MS) for small-molecule quantitation Stability and solubility assessment of 5-amino-1MQ under laboratory storage conditions Documentation Lot-specific COA available Batch and lot traceability Important Notice For research use only Not for human consumption Not intended to diagnose, treat, cure, or prevent any disease Quality & Manufacturing Lot-specific COA Lyophilized for transit stability
The elution was concentrated using an Amicon Ultra Centrifugal Filter (MWCO 100 kDa) and subjected to size-exclusion chromatography (SEC) on a Superdex 200 Increase 10/300 column that was pre-equilibrated with 20 mM HEPES pH 7.4, 100 mM NaCl, 2 mM MgCl 2 , 1 M peptide, 0.01% (w/v) LMNG and 0.0006% (w/v) CHS
Bagshawe KD (1983)
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