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NNMT inhibition doesn't directly affect gut motility, so prolonged GI symptoms suggest an individual sensitivity rather than a universal mechanism

This process not only supports weight loss but also helps optimize energy production by converting stored fat into usable fuel

Let your care team know about any symptoms while taking this medicine

DOI: 10.1186/s13073-026-01630-0 The study received funding from Wellcome, Medical Research Council, European Union Horizon 2020 Programme, the National Institutes of Health (grants U01-DK105535, U01-DK085545 and UM-1DK126185), the National Institute for Health Research Oxford Biomedical Research Centre, the Canadian Institutes of Health Research, the Novo Nordisk Foundation, Boehringer Ingelheim and Diabetes Australia