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At the clinical translation level, in addition to using classic surface markers such as CD90 and CD73 to establish the identity of MSC-Exos (128), clinical trials further indicate that a reduction in plasma Angiopoietin-2 (Ang-2) levels suggests improvement in endothelial injury and is closely related to the biological effects of MSC therapy (129), allowing it to be constructed as a precise molecular ruler for assessing tissue repair potential
The peptide initiates the cascade, but the cascade itself becomes self-sustaining for a defined period through feedback loops and secondary messenger systems
The chromophores trigger positive chemical changes that stimulate the mitochondria, producing more of the chemical signaling molecules that are key to accelerating tissue repair, reducing inflammation and pain, and creating an anti-inflammatory microenvironment in the brain
10.1038/bjc.2011.349 Br J Cancer
The risk of predictive DILI is related to the amount of drug-exposure and can be reproducible
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