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Likewise, activation of POMC/CART neurons promotes a sense of fullness and indirectly hinders the secretion of two peptides known for stimulating hunger: neuropeptide Y (NPY) and agouti-related peptide (AgRP) [12]
And Eli Lilly reports no specific evidence that Zepbound or Mounjaro increase fracture risk , and fractures are not listed as a safety signal in the current US prescribing information, although they continue to monitor safety data
More comprehensive insight into the effects of GLP-1 RAs on gastrointestinal and central nervous system functions is required
Some experimental research suggests these medications may promote M2 macrophage polarizationa phenotype associated with tissue repair rather than inflammationthough these findings require confirmation in clinical studies
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