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Intraneuronal aggregates of -syn that are intracellularly localized and bound to cellular membranes are capable of triggering ferroptosis through these aggregate-membrane interactions ( 3.2 Relationship between PD-related genes/proteins and ferroptosis PD pathophysiology is significantly influenced by genetic predisposition, with numerous gene loci linked to its development (133)

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While preparing this manuscript for submission, a study based exclusively in in vitro assays was published showing that the addition of 25 M BSO or the use of tools to delete GCLC inhibits the growth of Burkitt lymphoma cell lines under 2D culture conditions [42], seemingly suggesting a comparable susceptibility to glutathione starvation between TICs and differentiated tumor cells

Next, we will present a comprehensive analysis of the lactylation sites identified to be closely associated with IRI (Fig

Abnormal glucose and insulin metabolism has been implicated in Alzheimer disease as well