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Side effects also increase with dose, primarily gastrointestinal symptoms like nausea, vomiting, and diarrhea

Eur Heart J 8:179186 McGowan BM, Bruun JM, Capehorn M et al (2024) Efficacy and safety of once-weekly semaglutide 24 mg versus placebo in people with obesity and prediabetes (STEP 10): a randomised, double-blind, placebo-controlled, multicentre phase 3 trial

poor sleep raises hunger hormones and undermines progress

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It's important to note that upper arm injections typically require assistance from a caregiver due to the difficulty of self-administration at this site