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For women over 40 or those approaching menopause , hormonal changes can affect fat metabolism and peptide response

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GH and IGF-1 both play roles in tissue repair, collagen synthesis, and cellular regeneration

Such diseases encompass, but are not limited to, cerebral small vessel disease [19], Systemic sclerosis (SSc) [20], chronic obstructive pulmonary disease (COPD) [21], inflammatory bowel diseases, such as Chron disease and ulcerative colitis [22], coronary microvascular disease (CMD), often associated with increased risk of adverse effects [23]

Leslie SW, Soon-Sutton TL, Khan MA Male infertility