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Chir Main
These receptors vary in distribution in tissues and biochemical responses, and ligands binding to ER and ER can display different levels of agonism or antagonism depending on both the estrogen-responsive tissue type and the concentration of the ligand (Nilsson et al
This allows the liposomal delivery system to work without competing with a heavy meal
If regulatory submissions proceed as expected, the earliest plausible timeline for a market authorisation decision in the UK or Europe would be 2026 or 2027 though this is subject to the pace of regulatory review, the completeness of the submission package, and any additional data requests from the MHRA or EMA
Published 2015 Dec 10
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