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The cytoprotective effects of GLP-1(2836) are attenuated in the absence of sAC

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On the other hand, Yamamoto et al 148 found that GLP-1R activation could induce distinct c-fos expression in the adrenal medulla and neurons in autonomic control sites, including PVN, LH, PBL, NTS, and RVLM in rat brain, the medullary catecholamine neurons of brainstem can provide input to sympathetic preganglionic neurons, and GLP-1R agonists rapidly activated tyrosine hydroxylase transcription in brainstem catecholamine neurons like area postrema (AP)