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10.1016/S0076-6879(02)48630-2 Methods Enzymol

That matters because many of the most common side effects are gastrointestinal and are strongly influenced by how quickly patients escalate their dose

This distinction proves crucial as current clinical guidelines consider 5% weight reduction the threshold for meaningful health benefits

For weight management, lack of at least 5% weight loss by 12 weeks at the maintenance dose warrants discussion about alternative strategies or dose optimization