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Sandstrom et al., 1993) might now seem related to inhibition of NCC

Anti-Aging & Wrinkle Reduction Boosts collagen for firmer, younger-looking skin

A 2021 study found NMN (NAD precursor) improved insulin sensitivity, but larger randomized trials are needed to establish efficacy and optimal dosing in humans

Retinoid mechanisms differ fundamentally from GHK-Cu by directly binding nuclear receptors controlling gene expression and cell turnover rather than providing enzymatic cofactors supporting natural processes, creating stronger effects but also more pronounced dependency where discontinuation often triggers rebound effects

Sekhar et al, 1997