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Application Considerations in Research: Start with a low concentration and frequency

Some of these effects are in fact analogous to those previously observed by reducing beta cell/islet cholesterol with simvastatin: for example, both manipulations led to a reduction in GLP-1R plasma membrane lateral diffusion under vehicle conditions, as well as acute increases in GLP-1R-induced cAMP and islet insulin secretion responses

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Non-adherence to medication regimens in individuals with depression who develop diabetes may contribute to the increased observed risk of complications such as cardiovascular disease, neuropathy, and retinopathy [139]

So they lost the same amount of weight, but they did it not with the drug, but just by diet alone