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Important for tissue healing and repair, though also a concern in cancer contexts where new vessels can supply tumors
Different species can respond differently to hypoxic stress, and primate or human studies are needed to validate clinical relevance
In the early stage of tumor colonization or growth, activated immune cells contribute to a tumor-suppressive inflammatory microenvironment that hinders tumor development, whereas long-term persistent antigenic stimulation, the activation of immunosuppressive cells and metabolic stress prompt the tumor to escape from the surveillance of the immune system and continue to grow, which is known as immune escape of the tumor (70,71)
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Detection methods include mass-spectrometry-based urine and blood assays that can identify exogenous IGF-1 analogues by their structural differences from endogenous hormone [21]
