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Although the principal cause of pharmacological actions of sulfonylureas is determined, considerable data have accrued suggesting that multiple targets, in addition to K ATP channels, are impacted by these chemicals to induce pleiotropic effects, which may be possibly responsible for the pharmacological effectiveness and adverse effects

D., Westphal, J

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These cells are sensitive to inflammation and oxidative stress, especially with aging or poor diet

If combining, reduce thyroid hormone dose by 2550% and monitor for hyperthyroid symptoms: excessive sweating, tremors, palpitations, and anxiety