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Independent research groups outside the original Sikiric-Seiwerth laboratory have published on the musculoskeletal soft-tissue findings, providing cross-laboratory replication of the core repair-model claims (PMID 30915550)

While its expression pattern varies across tumor types, CHAC1 is frequently upregulated in aggressive malignancies, such as breast and ovarian cancer, where it correlates with advanced tumor differentiation and potentially serves as a prognostic marker

Most investigations addressing the state of chronic low-grade inflammation in PCOS have focused on circulating C-reactive protein (C-CRP), TNF, interleukin-6 (IL-6), and IL-18 levels

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