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The first is to add a prandial insulin to the treatment regimen, either by adding a RAI prior to the largest meal of the day, with addition at other meals in stages if required (basal-plus), adding RAI at all meals (basal-bolus), or by switching to a premixed (biphasic) insulin formulation of intermediate- and short-acting insulins
Portugal-Cohen et al
The decision to use weight loss injections should be made individually, considering health, medical history, and lifestyle
PMC12151102
Existing NICE-approved therapies, including semaglutide and tirzepatide, already offer substantial benefits for eligible patients and are available through NHS pathways
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