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Participants with a BMI 35 kg/m and female participants experienced a higher percentage of weight loss following retatrutide treatment
When investigating elevated B12, additional tests such as active B12 (holotranscobalamin), methylmalonic acid, and homocysteine may help clarify true B12 status
However, direct GH replacement carries risks associated with supraphysiological dosing
A multicenter trial in Alzheimers disease found no benefit on cognitive or functional outcomes while shifting some biomarkers, a smaller trial in healthy older adults reported improved memory and hippocampal connectivity, and the overall assessment is that it is unlikely to help most healthy adults and that the evidence is not conclusive
doi: 10.2147/OTT.S255226 46 ChenYDengYZhangBGongC-X
