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These effects are usually temporary and tend to improve over time

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P = 0.06) ( The reported CV benefits were not associated with an increase in risk of severe hypoglycemia, retinopathy, or pancreatic adverse effects ( Moreover, a very recent multicenter, double-blind, randomized, placebo-controlled trial (the SELECT trial), showed that weekly 2.4 mg subcutaneous semaglutide was superior to placebo in reducing the risk of CV death, nonfatal MI, or nonfatal stroke at a mean follow-up of 39.8 months