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Clinical trials evaluating semaglutide safety, including the SUSTAIN and STEP trial programs which enrolled thousands of participants, did not identify UTIs as a significant adverse event associated with the medication

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To investigate whether semaglutide promotes angiogenesis through PCSK5 following MI, semaglutide (60 g/kg via subcutaneous injection) or a vehicle control was administered to Pcsk5 WT and Pcsk5 ECKO mice daily post-MI (Fig