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B12-conjugated GLP-1 analogs show reduced brain penetration due to the active transport mechanisms that move B12 through specific carrier proteins rather than through passive diffusion

There are also concerns about nutritional deficiencies , as the restrictive nature of keto combined with reduced appetite may result in inadequate intake of essential nutrients, fibre, and micronutrients

People often use Ozempic as shorthand for the whole category, but in Australian medicine information, Wegovy is the semaglutide product specifically indicated for chronic weight management, while Ozempic is listed for type 2 diabetes care

The authors thank Debbie Armstrong and Feiyue Wang (University of Manitoba) for ICP-MS analysis