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The tripeptide glycyl-L-histidyl-L-lysine was first isolated from human serum by Pickart and Thayer, whose 1973 paper in Biochemical and Biophysical Research Communications documented that the synthetic tripeptide prolongs survival of normal liver cells at nanomolar concentrations, establishing the foundational observation that small peptide fragments in circulation have tissue-maintenance functions

PloS One 13, e0193473

Abbreviations BCAAs: Branched-chain amino acids CIs: Confidence intervals DR: Dorsal raphe fMRI: Functional MRI GLP-1RAs: Glucagon-like peptide-1 receptor agonists GWAS: Genome-wide association studies IGF: Insulin-like growth factors IR: Insulin receptor IVW: Inverse-variance weighted LD: Linkage disequilibrium LIRA: Liraglutide LPS: Lipopolysaccharide MDD: Major depressive disorder MHC: Histocompatibility complex MR: Mendelian randomization OCD: Obsessive-compulsive disorder ORs: Odds ratios PGC: Psychiatric genomics consortium RCTs: Randomized controlled trials T2DM: Type 2 diabetes mellitus UKB: UK biobank References U.S

View source SURMOUNT-1 tirzepatide trial New England Journal of Medicine Peer-reviewed Phase 3 trial results for tirzepatide in adults with obesity or overweight

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