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Topiramate has similar benefits for weight reduction in psychiatric patients, but cognitive impairment limits its usage (McIntyre RS et al, Am J Psychiatry 2024;181(1):2638)
The real question for cagrilintide isnt whether it beats tirzepatide solo, but whether its mechanism earns it a complementary role: either as part of a combination like CagriSema or as a standalone option for people who need something outside the GLP-1 family
Like any tool, it only makes sense in the right hands for the right job.
Thats why the Trump administration is doing it under its authority to run a temporary demonstration project to test new payment and coverage
It is not an approved drug or dietary supplement ingredient and is generally categorized as a research-only compound
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