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In prerenal AKI, the kidney may function normally, but there is a decrease in either intravascular volume or arterial pressure, which results in a reduced glomerular filtration rate (GFR) (Macedo and Mehta 2009)

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Study participants receiving active treatment saw three times the weight loss experienced by those in the placebo group

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[1] Retatrutide: What the Evidence Actually Shows Retatrutides pivotal obesity dataset is a Phase 2, double-blind, randomised, placebo-controlled trial in adults with obesity (or overweight plus a weight-related condition), testing once-weekly doses up to 12 mg over 48 weeks