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While extensive studies have focused on leptins actions in the hypothalamus in the regulation of feeding and energy metabolism [10, 11], LepRb is also highly expressed in extra-hypothalamic brain regions including the hippocampus, which is implicated in mood regulation [4, 12,13,14]

Its recommended to seek medical advice if experiencing the following or if these issues persist or worsen: swelling sensation in the body redness and pain at the injection site temporary itching of the skin mild diarrhea There may also be a risk of: congestive heart failure anaphylaxis polycythemia vera, which is a type of blood cancer peripheral vascular thrombosis, which involves blood clots pulmonary edema If experiencing difficulty breathing, swelling, and hives, patients must seek emergency medical help

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