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GLP-1(936) depletes docked granules pool The fact that GLP-1(936) remains glucagonostatic regardless of whether glucagon secretion is triggered by low glucose alone, membrane depolarisation or receptor-induced elevation of cAMP suggests it may act late in the secretory process, possibly at the level of exocytosis itself

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In summary, we found that MOTS-c is reduced with aging and senescence in -cells and the extent of MOTS-c levels upon oxidative stress declines

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Nutr Clin Pract