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However, it is also a very important oxidation-regulating compound, thus melanin serves as a protective mechanism against UV exposure

In the acidic tumor microenvironment, excessive H + interferes with the re-exposure of active catalytic sites, and inert CNPs no longer interfere with the generation of ROS mediated by chemotherapy for cancer treatment

It was found that the increase in ROS after high-dose vitamin C treatment also induced DNA damage and PARP activation in KRAS or BRAF transformed cells

For elution of the target protein, the interaction to the ligand is resolved by changing the buffer conditions, for example, the pH value, or by adding a specific competitor that supplants the target protein from the ligand resulting in dissociation of the target, while the ligand remains immobilized on the stationary phase

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