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While this is usually negligible, it can add up over multiple doses from the same vial
Regulatory Toxicology and Pharmacology, 114 , 104665
the clinical relevance of this finding in humans is unknown, and in UK and EU prescribing information this is noted as a precaution rather than a formal contraindication but individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2) should discuss this with their doctor
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