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It has been indicated that prolonged administration of MSG (4 mg/g) significantly induces apoptosis in a time- dependent manner in the rats thymocyte cells via disturbing the fine balances between prooxidant-antioxidant system, with excessive production of ROS and resulting oxidative stress status [46]
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Marquez-Meneses JD, Olaya-Bonilla SA, Barrera-Carreo S, Tibaduiza-Arvalo LC, Forero-Crdenas S, Carrillo-Vaca L, Rojas-Rodrguez LC, Calderon-Ospina CA, Rodrguez-Quintana J
Therefore, we hypothesized that Sirt7 might bind with DNA on nucleosomes via C -terminal basic region, and its nucleosome-binding would enhance deacylase activity of Sirt7
Bolen S, et al
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