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Isosteviol, a commonly used sweetener-component, and duloxetine, an antidepressant, synergistically inhibited Roseburia intestinalis , a bacterium previously linked to glucose homeostasis, and Parabacteroides merdae , a prevalent commensal linked to healthy microbiota
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Furthermore, elevated XO activity correlates with adipose tissue dysfunction, potentially exacerbating insulin resistance through ROS-NF-B signaling ( 3.5.3 Therapeutic adherence challenges Chronic conditions (e.g., gout, diabetes, and psychiatric disorders) require prolonged pharmacotherapy (e.g., febuxostat or antipsychotics), yet patient adherence wanes with complex regimens (e.g., twice-daily dosing) (Lnu et al., 2024)
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