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In addition, the absence of the P53 tumor suppressor gene can obstruct Gln utilization by decreasing GLS2 levels inside cells and boosting ROS levels ( 4 Targeting Gln to enhance clinical treatment of tumors The reprogramming of Gln metabolism is strongly linked to the aggressive development of tumors

Although it cannot yet be determined whether vitamin B 12 deficiency plays a causal role in depression, it may be beneficial to screen for vitamin B 12 deficiency in older individuals as part of a medical evaluation for depression

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