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Semaglutide (Smg), a GLP-1 receptor agonist, enhances KLB mRNA expression significantly through the activation of the cAMP signaling pathway, particularly via the phosphorylation of PKA and cAMP response element-binding protein (CREB)

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However, strategies to enhance the actions of these cells can be beneficial in certain conditions where a loss, rather than an excess of fibroblast activity is present