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P-T (placebo to tesamorelin) refers to the group of patients who received placebo for Weeks 0-26 and were switched to tesamorelin (treated open label) for Weeks 26-52

This involves giving large doses of B12 injections, possibly every day or week, for a certain time

Contact your GP or diabetes specialist if blood glucose control is inadequate, you experience significant side effects (particularly persistent gastrointestinal symptoms or severe abdominal pain), develop signs of hypoglycaemia, or have questions about your medication regimen

doi: 10.1056/NEJMoa2302392

Specifically, it is found in blood plasma, saliva and urine