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3.2 Metal-organic frameworks The MOFs, assembled from metal ions and organic ligands via coordination bonds, have attracted growing interest in biomedical applications owing to their biocompatibility, biodegradability, adjustable structures, and diverse functions (Liang and Liang, 2020
Among the various applications for CPP-aided transepithelial transport, antidiabetic peptides, such as insulin, and exendin-4, were studied for its systemic and brain delivery via the nasal administration route (Figure 3)
No serious cases of low blood sugar or thyroid cancer were reported
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