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As the primary source of reducing equivalents, NADPH is primarily produced by glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase in the pentose phosphate pathway (PPP)

Retatrutide is an investigational single-peptide compound designed to activate three metabolic hormone receptors: GIP, GLP-1, and glucagon

For example, nausea affected 45% of people taking the highest dose of retatrutide, compared with 11% of people taking placebo

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