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The ice crystals that form during freezing physically tear apart the peptide bonds

Because preservative effectiveness is only required to be demonstrated for 28 days after first entry, standard multiple-dose vial practice, reflected in CDC injection safety guidance, is to date the vial at first puncture and discard it 28 days later

At effective doses, omega-3 fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid, have distinct effects on membrane structure, lipid dynamics, and rates of membrane lipid oxidation

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