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Abbreviations BCAAs: Branched-chain amino acids CIs: Confidence intervals DR: Dorsal raphe fMRI: Functional MRI GLP-1RAs: Glucagon-like peptide-1 receptor agonists GWAS: Genome-wide association studies IGF: Insulin-like growth factors IR: Insulin receptor IVW: Inverse-variance weighted LD: Linkage disequilibrium LIRA: Liraglutide LPS: Lipopolysaccharide MDD: Major depressive disorder MHC: Histocompatibility complex MR: Mendelian randomization OCD: Obsessive-compulsive disorder ORs: Odds ratios PGC: Psychiatric genomics consortium RCTs: Randomized controlled trials T2DM: Type 2 diabetes mellitus UKB: UK biobank References U.S

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Butyrogenesis is specialized to select Firmicutes taxa expressing butyryl-CoA:acetate CoA-transferase, with Faecalibacterium prausnitzii being a key producer (Louis et al., 2010)

Research reported in this publication was also supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Award Number P50NS053672 to K.P.C