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For transduction, 200 l lentiviral supernatant was thawed on ice and added to HCC-1806 cells together with 8 mg ml 1 Polybrene (hexadimethrine bromide

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According to statistics, there are currently approximately 50 million people living with AD worldwide, and this number is expected to increase to 152 million by 2050 as the population ages, making it a major challenge for global public health (Dissanayaka et al., 2024)