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Symptoms include: Nausea Vomiting Loss of appetite Fatigue and weakness Sleep problems Changes in how much you urinate Decrease mental sharpness Muscle twitches and cramps Swelling of feet and ankles Persistent itching Chest pain (if fluid builds up around the heart) Shortness of breath (if fluid builds up in the lungs) High blood pressure that is difficult to control Nephrotic syndrome is a group of symptoms showing your renal system is not working as well as it should