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Physical Examination: mild cyanosis may be detected along with a wide pulse pressure and cardiomegaly
9% involved prescription opioids (e.g., oxycodone, hydrocodone) without fentanyl or heroin
You could end up with nausea, vomiting, and diarrhea, which are fairly common if you're not mitigating it through diet and lifestyle
141,142 Recurrent somatic mutation of residues are mainly located at enzymatic active sites that bind to isocitrate, typically at R132 including R132H, R132L, R132S, R132C, and R132G in IDH1, and R140Q or R172K in IDH2
PLoS ONE 9 , e94752 (2014)
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