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Bull.,2006, 29, 1554-1558 17
Glucose metabolism in TC Ever since Warburg laid the foundation for the integral view of cancer biology [31] in which cancer metabolism shares the equal significance with signal transduction and transcription [32], the altered glucose metabolism has been the most investigated [33] and proven to play an important role in TC development [34]
The resulting albumin-cagrilintide complex: Is too large (~70,000 Da total) for glomerular filtration Is partially shielded from proteolytic degradation by albumin's spatial occupancy Functions as a reversible depot, slowly releasing free cagrilintide as albumin binding equilibrium dynamics allow Only the unbound (free) fraction of cagrilintide is pharmacologically active -- it binds amylin and calcitonin receptors in the central nervous system and periphery -- while the albumin-bound fraction serves as a circulating reservoir
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Alpino Gd C, Pereira-Sol GA, Dias Md Me, Aguiar ASd, Peluzio Md CG
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