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For context on SAMe and related evidence limits, see the NIH NCCIH resource S-Adenosyl-L-Methionine (SAMe): In Depth

Our bodies produce glutathione naturally , but several factors can cause those levels to dip: The natural aging process Environmental pollutants and toxins High levels of daily stress Poor dietary choices Occasional alcohol consumption When these levels drop, our cells may become more vulnerable to the wear and tear of daily life