Symptoms include tiredness, weakness, shortness of breath with mild exertion, and cold hands and feet
Because SNAC protects semaglutide from pH-dependent degradation and the consumption of food leads to an increase in gastric pH, the effect of food and water on systemic semaglutide exposure was investigated
No improvement on the other hand would suggest that MTHFR may not be the dominant cause of fatigue even if MTHFR testing is positive
doi:10.1186/1472-6904-12-8 149
Pang HB, Braun GB, Friman T, Aza-Blanc P, Ruidiaz ME, Sugahara KN, Teesalu T, Ruoslahti E