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In the lixisenatide-treated group, a significant increase in HR was observed only at 5 h post-dosing, and the mean HR per day remained unchanged (69.1 8.6 to 71.7 10.6 bpm

JAK inhibitors represent another class of targeted therapy, but like anti-TNF agents, they come with significant immunosuppressive effects

SSRIs can be associated with modest weight changes in some individuals, but this varies widely and is generally small compared with tirzepatide's effect on appetite and weight

Physical examination should assess for signs of chronic liver disease, though these are often absent in early MASLD