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This stepwise escalation principle mirrors the approach used for licensed medicines such as semaglutide (Wegovy, UK SmPC available via the electronic Medicines Compendium) and tirzepatide (Mounjaro, UK SmPC available via the electronic Medicines Compendium), both of which are approved by the MHRA and recommended within relevant NICE guidance for specific indications
The results highlight the powerful effect of retatrutide, a first-in-class triple agonist, on body weight, pain and physical function
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Contact your doctor if you cannot keep fluids down for more than 24 hours, if you experience severe abdominal pain, if you have a heart rate above 100 beats per minute at rest, or if you feel significantly worse after day four rather than better
