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Medications included in the meta-analysis were tirzepatide (Zepbound, Eli Lilly), semaglutide (Wegovy, Novo Nordisk), liraglutide (Saxenda, Novo Nordisk), phentermine/topiramate (Qsymia, Vivus), naltrexone/bupropion (Contrave, Nalpropion Pharmaceuticals) and orlistat (Xenical, Roche)
Unlike Melanotan 2, which non-selectively activates MC1R, MC3R, MC4R, and MC5R, Melanotan 1s selectivity for MC1R makes it a valuable research tool for isolating melanocortin-1 receptor biology from the broader melanocortin receptor system
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