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Phase I breaks it down into metabolites, some of which are reactive and potentially harmful

2.6 Meta-analysis Meta-analysis was performed using the R statistical program, R version 4.4.2 (The R Foundation for Statistical Computing, Wirtschaftsuniversitt Wien, Vienna, Austria) ( 3 Results 3.1 Study selection and characteristics The search strategy identified 2,183 potential articles: 1,299 from PubMed, 353 from Scopus, 527 from Embase, 4 from manual screening

These effects could be attributed to fructose-mediated glycation, increased levels of RCS and ROS, AGE accumulation, and subsequent activation of RAGE (18, 2126)

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